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Therapeutic apheresis is a general term for treatments that remove harmful proteins, chemicals, or cells in the blood that contribute to disease. The following are different types of therapeutic apheresis ordered based on a patient’s specific condition:

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  • plasmapheresis (or plasma exchange),
  • white blood cell depletion,
  • photopheresis,
  • red blood cell exchange,
  • platelet depletion.


Similar to the apheresis blood donation process, an automated machine separates blood components, isolates the targeted substance and returns the remaining components to the patient.

Who Needs It?
Therapeutic apheresis (TA) is helpful for patients facing a variety of medical conditions. It can be used to treat patients with blood disorders, kidney problems, metabolic diseases, and neurologic disorders. It is also indicated in patients with autoimmune diseases. In autoimmune conditions, the body’s immune system mistakenly attacks its own tissues.

Plasma exchange is performed to remove antibodies in the blood that threaten the body’s healthy tissues. Another example of a disease where plasma exchange is beneficial is thrombotic thrombocytopenia purpura (TTP). For this type of blood disorder, TA (plasma exchange) removes the offending agent and is replaced with donated plasma.

A type of TA called Cytapheresis can be used short term in patients with leukemia to reduce the number of white cells until they can be controlled by other medications.

What Happens During Therapeutic Apheresis?
These procedures are performed by an Oklahoma Blood Institute (OBI) RN under the direction of an OBI physician. You will be asked to sign a consent form which allows the procedure to be performed. Some of your blood is removed through a vein which then enters a medical device called a blood cell separator for processing. After your blood is processed, it is returned to you.

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The kit that is used is a sterile, one time use tubing kit. Sometimes the procedure can be done using veins in the arm; however, most cases require that a catheter be placed in a large vein (central line.) The insertion of the central line is done at the hospital.

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Most apheresis procedures use albumin as a replacement fluid; however, certain medical conditions may require that you receive a blood component. You will be asked to sign a blood transfusion consent form if blood is given during your procedure.

Are There Side Effects?

An anticoagulant is given during the procedure, and some patients may feel tingling around the lips, or a pins and needles feeling in the fingers or toes. It is important to tell the nurse if this happens. Some patients may feel dizzy, lightheaded or cold during the procedure. Some patients feel tired after a procedure, but most are able to continue routine daily activities.

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How Long Does Therapeutic Apheresis Take?
This depends on the type of procedure your doctor has ordered. Usually the procedure takes between 2-3 hours.

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For more information, contact 405-297-5801 or 800-375-8778